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Examining the microbiome changes with Fecal Microbiota Transplantation (FMT) for children with recurrent Clostridium difficile infection

  • Examining the microbiome changes with Fecal Microbiota Transplantation (FMT) for children with recurrent Clostridium difficile infection
  • Aim: to examine the changes  in fecal bacteria before and after fecal transplant
  • Eligibility: Children who have had at least 3 recurrences of Clostridium difficile infection and are clinically undergoing fecal microbiota transplantation. These can be children both with and without  inflammatory bowel disease (IBD).
  • Principal Investigator: Suchitra Hourigan
  • Publications: Hourigan SK, Chen LA, Grigoryan Z, Laroche G, Weidner M, Sears CL, Oliva-Hemker M. Microbiome changes associated with sustained eradication of Clostridium difficile after single faecal microbiota transplantation in children with and without inflammatory bowel disease. Aliment Pharmacol Ther. 2015 Sep;42(6):741-52. http://www.ncbi.nlm.nih.gov/pubmed/26198180.​
  • Hourigan SK, Oliva-Hemker M. Fecal Microbiota Transplantation in Children - A Brief Review. Pediatr Res. 2016 Mar 16. [Epub ahead of print].  http://www.ncbi.nlm.nih.gov/pubmed/26982451